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Computational Modelling to Characterize and optimize dendrimer based nanocarriers for SiRNA

Acronimo COPD

Abstract The project will focus on ad hoc dendrimer-based systems suitable for inhalator purpose and able to guarantee an high Tumor Necrosis Factor Alpha (TNF-a) silencing as a novel strategy to target the pulmonary disease Chronic Obstructive Pulmonary Disease (COPD). Our research will be focused on molecular modelling to perform an accurate evaluation of the physico-chemical and molecular properties, as well as on the mechanism of action of several functionalized dendrimers which has shown to be effective in delivering siRNA targeting TNF-a. The project will benefit from the open collaboration with Prof. Elias Fattal, University of Paris-Sud in Châtenay-Malabry, together with Prof. Jean-Pierre Majoral, Laboratoire de Chimie de Coordination in Toulouse. These experimental partners will support the project with complementary experimental activities for guiding and validating theoretical calculations. Results of our modelling activities not only will directly contribute to Profs. Fattal and Majoral research, bridging a current lack, but could also open new frontiers for the development of dendrimers-based siRNA carriers to be applied to pulmonary diseases.

Enti SUPSI coinvolti Istituto Dalle Molle di studi sull'intelligenza artificiale

Responsabili Andrea Danani

Data di inizio progetto 1 novembre 2016

Data di chiusura progetto 31 ottobre 2018