Over the years, the Institute for Applied Sustainability to the Built Environment (ISAAC) has collaborated with a number of research institutes in Switzerland and abroad.
ISAAC works closely with representatives from Swiss Public Administration bodies, such as the Federal Energy Office (UFE) and the Section for the protection of the air, water and soil (SPAAS). The Institute has many persons of reference in various research sectors developed together with regional, national and even international companies.  
As the only representative from Southern Switzerland, ISAAC is an active member of the BRENET competence network (Building and Renewable Energies Network of Technology).